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Open access

ISSN: 1874-4710
e-ISSN: 1874-4729

Radioprotective effect of pyrogallol nanocomposite on radiation-induced toxicity in spleen and bone marrow of BALB/c mice

Radiotherapy is a first-line treatment for cancer that utilizes high-energy ionizing radiation to eliminate cancer cells. However, its therapeutic efficacy is often limited by their toxicity to healthy...

Technetium-99m labelled fluoroquinolone-based radiotracers for infection imaging: A critical review

Proper distinction between bacterial infection and sterile inflammation is one of the major issues in molecular imaging. Though radiolabelled leukocytes and [18F]fluorodeoxyglucose ([18F]FDG) have retained...

Clinical diagnosis and treatment of refractory neuro-ischemic diabetic foot ulcer: A case report

Neuro-ischemic diabetic foot ulcers (DFUs) associated with advanced peripheral artery disease and severe neuropathy pose a considerable challenge for limb preservation, especially when repeated revascularization...

Cardiac function measurement: CMR versus CT imaging using various reconstruction matrices

To evaluate the consistency of cardiac function measurements between cardiac magnetic resonance (CMR) and coronary computed tomography angiography (CCTA) across various reconstruction matrices and to...

Next-generation therapeutic strategies in prostate cancer: Integrating targeted therapy, radioligand therapy, and precision oncology

Prostate cancer continues to present major clinical challenges, particularly in advanced and metastatic settings where therapeutic resistance and tumor heterogeneity limit the long-term efficacy of...

Diagnosis and comprehensive therapy for multiple primary lung cancer: A narrative review

The increasing use of chest computed tomography (CT), positron emission tomography-computed tomography (PET-CT), and lung cancer screening has led to more frequent detection of multiple pulmonary lesions....

Parotid MRI for the evaluation of primary Sjögren's syndrome: A meta‑analysis

This study aims to assess the diagnostic utility of parotid gland magnetic resonance imaging (MRI) in patients with primary Sjögren’s syndrome (pSS)....

A deep learning fusion model based on CT radiomics and EBUS for preoperative prediction of mediastinal lymph node metastasis in lung adenocarcinoma

Preoperative prediction of mediastinal lymph node metastasis in lung adenocarcinoma is of great significance for clinical decision-making. Accurate assessment of mediastinal lymph node metastasis guides...

Prospects of artificial intelligence in multimodal integration of methylation and imaging features for precision cervical cancer screening

Cervical cancer remains a major public health threat to women worldwide, and early screening is critical for reducing its incidence and mortality. Although human papillomavirus (HPV)-based screening...

The algorithmic isotope: artificial intelligence and the future of radiopharmaceutical medicine

Nano-radiopharmaceuticals at the crossroads: A critical analysis of advances, limitations, and clinical trajectories in imaging and therapy

Nano-radiopharmaceuticals have re-surfaced under the limelight of nuclear medicine at the intersection of nanotechnology, radiochemistry and theranostics. Even though there has been much preclinical...

Impact of catheter removal timing and an ultrasound/DSA-guided stratified management strategy on outcomes of difficult PICC removal in malignant tumor patients: A single-center retrospective study of 61 cases

To evaluate the impact of catheter removal timing and an ultrasound/digital subtraction angiography (DSA)-guided stratified management strategy on outcomes in malignant tumor patients experiencing difficult...

Synergy of imaging modalities and omics profiling: Unlocking unmet clinical potentials of novel radiopharmaceuticals

Radioprotective nanomedicines: New horizons in mitigating radiation-induced tissue injury

Ionizing radiation remains indispensable in cancer therapy, diagnostics, and industrial and space applications, yet radiation-induced normal tissue injury continues to limit therapeutic efficacy and...

A novel applicator for beta radionuclide brachytherapy of skin cancer using 188Re source

Brachytherapy (BT) is a useful modality for treating small, early-stage skin cancers. Beta-emitting sources have also been widely investigated due to their inherently steep dose fall-off, which helps...

Research progress on multimodal monitoring combined with biomarkers in critical care management strategies after neurointerventional surgery

Neurointerventional techniques are core treatments for cerebrovascular diseases, yet postoperative complications, including ischemia-reperfusion injury, hyperperfusion syndrome, vasospasm, and delayed...

Development and validation of a dual-modal predictive model combining CT radiomics and clinical factors for adjacent vertebral refracture after PVP/PKP

To establish a dual-modal predictive model combining CT radiomics and clinical factors for adjacent vertebral fractures (AVF) after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP),...

Characteristics of carotid plaques combined with total cerebral small vessel disease burden for predicting recurrence of Ischemic stroke

To investigate the predictive value of carotid plaque characteristics combined with total cerebral small vessel disease (CSVD) burden for recurrent ischemic stroke....

World AI models in cardiology: Toward causal, dynamic, and multimodal intelligence in cardiovascular imaging

Artificial intelligence in cardiovascular imaging has largely advanced through task-specific systems that analyze static, single-timepoint imaging data. Moreover, current large language and generative...

Advances in radiomics for predicting lymph node metastasis in rectal cancer

Rectal cancer is a common malignancy with substantial morbidity and mortality worldwide. Lymph node status is a key determinant of prognosis and treatment selection; therefore, accurate preoperative...

Optimization of reaction conditions and process automation for [99mTc]Tc-PSMA-I&S preparation on a GAIA® synthesizer

Radioguided surgery (RGS) using PSMA radioligands emerged as a valuable approach for the detection of metastatic lymph nodes in prostate cancer. [99mTc]Tc-PSMA-I&S is specifically designed for combined...

Theranostic applications of PSMA-targeted radiopharmaceuticals: From molecular design to clinical translation and emerging paradigms

Theranostics is an innovative concept in nuclear medicine that combines molecular imaging with targeted radionuclide therapy. PSMA is the best-studied and most clinically utilized oncological theranostic...

MPI SPECT and GSPECT in type 2 diabetes mellitus patient: Combined perfusion and functional imaging for cardiovascular risk stratification

Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Early detection of subclinical coronary and myocardial injury is therefore essential...

Next‑generation theranostic radiopharmaceuticals: Integrating alpha emitters and nanocarriers for precision oncology

Alpha-emitting radionuclides, characterized by high-linear energy transfer (LET) and short path length, are emerging as potent tools in targeted cancer therapy. When combined with advanced nanocarrier...

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