The role of 131I in the treatment and management of thyroid cancer
January 2026
For individuals with thyroid cancer, the most common cause of mortality worldwide is recurrent, metastatic disease. Radioactive iodine (RAI) remains the cornerstone of treatment for these patients....
Open problems for the preparation and quality control of Ac-225 radiopharmaceuticals
January 2026
The aim of this brief review is to analyze the persistent chemical and radiochemical hurdles that still hinder the development of clinically useful actinium-225 (225Ac) radiopharmaceuticals for alpha-targeted...
Next‑generation theranostic radiopharmaceuticals: Integrating alpha emitters and nanocarriers for precision oncology
July 2026
Alpha-emitting radionuclides, characterized by high-linear energy transfer (LET) and short path length, are emerging as potent tools in targeted cancer therapy. When combined with advanced nanocarrier...
Theranostic applications of PSMA-targeted radiopharmaceuticals: From molecular design to clinical translation and emerging paradigms
July 2026
Theranostics is an innovative concept in nuclear medicine that combines molecular imaging with targeted radionuclide therapy. PSMA is the best-studied and most clinically utilized oncological theranostic...
The PSMA paradox: How biology, androgen signaling, and therapy sequencing shape Lu-177 efficacy
July 2026
MPI SPECT and GSPECT in type 2 diabetes mellitus patient: Combined perfusion and functional imaging for cardiovascular risk stratification
July 2026
Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Early detection of subclinical coronary and myocardial injury is therefore essential...
Radioprotective effect of pyrogallol nanocomposite on radiation-induced toxicity in spleen and bone marrow of BALB/c mice
September 2026
Radiotherapy is a first-line treatment for cancer that utilizes high-energy ionizing radiation to eliminate cancer cells. However, its therapeutic efficacy is often limited by their toxicity to healthy...
Next-generation therapeutic strategies in prostate cancer: Integrating targeted therapy, radioligand therapy, and precision oncology
September 2026
Prostate cancer continues to present major clinical challenges, particularly in advanced and metastatic settings where therapeutic resistance and tumor heterogeneity limit the long-term efficacy of...
Optimization of reaction conditions and process automation for [99mTc]Tc-PSMA-I&S preparation on a GAIA® synthesizer
July 2026
Radioguided surgery (RGS) using PSMA radioligands emerged as a valuable approach for the detection of metastatic lymph nodes in prostate cancer. [99mTc]Tc-PSMA-I&S is specifically designed for combined...
Case report of systemic inflammatory response syndrome in refractory gout mimicking infective endocarditis: Diagnosis via PET–CT and successful treatment with firsekibart
July 2026
Severe gout can manifest as systemic inflammatory response syndrome (SIRS), closely mimicking infective endocarditis (IE) and presenting a diagnostic challenge, particularly in patients with complex...
Radioprotective effects of curcumin during radiotherapy: Critical evaluation of preclinical and clinical evidence
July 2026
Radiation therapy is a key treatment modality for cancer, effectively targeting malignant cells. However, the treatment is often associated with harmful side effects due to radiation-induced damage...
Synergistic role of multi-omics analysis combined with multimodal imaging in precision diagnosis and treatment of thoracic and abdominal tumors
May 2026
Thoracic and abdominal tumors, such as lung, breast, liver, and colorectal cancers, are characterized by high incidence and mortality rates, posing a significant threat to global health. Traditional...
Livoscan a deep learning framework with attention mechanisms for accurate liver fibrosis detection
July 2026
Liver fibrosis is a progressive disease that is progressive in nature and develops due to chronic liver injuries that can ultimately progress into cirrhosis and cancer of the liver if not detected early....
Convergence methodologies for PSMA-targeted radiotheranostics: A transformative blueprint for precision prostate cancer management
July 2026
PSMA-targeted radiotheranostics has become an important component of precision prostate cancer management, supported by recent clinical trials of ^177Lu-PSMA-617 and ^225Ac-PSMA ligands. Concurrently,...
Radiopharmaceuticals for microbiome imaging: A narrative review of emerging approaches to mapping host–microbe interactions
January 2026
The human microbiome has immense effects on immunity, metabolism, and therapeutic response, but non-invasive in vivo visualization is underdeveloped. Radiopharmaceuticals, traditionally applied in oncology...
Proteomics- and bioinformatics-based identification of regulators of radiosensitivity in lung cancer
July 2026
Radiotherapy resistance is a major challenge in lung cancer (LC) treatment, affecting patient outcomes. The protein networks underlying radiotherapy response remain incompletely understood....
Accuracy study of deep learning-based synthetic CT images for adaptive radiotherapy of pelvic tumors
January 2026
To evaluate the accuracy of deep learning conversion of cone-beam computed tomography (CBCT) into synthetic CT (sCT) for adaptive pelvic radiotherapy and to inform clinical application....
Research progress on precision prevention and treatment of prediabetes based on multi-omics-imaging-pharmacology synergistic mechanisms from an integrated Chinese and Western medicine perspective
July 2026
This paper reviews recent advances in the precise management of prediabetes, adopting an integrative perspective that synergizes multi-omics, radiomics, and pharmacological insights from both traditional...
Technetium-99m labelled fluoroquinolone-based radiotracers for infection imaging: A critical review
September 2026
Proper distinction between bacterial infection and sterile inflammation is one of the major issues in molecular imaging. Though radiolabelled leukocytes and [18F]fluorodeoxyglucose ([18F]FDG) have retained...
GATA3 contributes to radiation-induced lung injury by regulating ESM1-mediated NF-κB signaling and inflammatory responses
May 2026
Radiation-induced lung injury (RILI) is damage to normal lung tissue caused by thoracic tumor radiotherapy (RT), but effective interventions are lacking and its molecular mechanisms remain unclear....
Nano-radiopharmaceuticals at the crossroads: A critical analysis of advances, limitations, and clinical trajectories in imaging and therapy
September 2026
Nano-radiopharmaceuticals have re-surfaced under the limelight of nuclear medicine at the intersection of nanotechnology, radiochemistry and theranostics. Even though there has been much preclinical...
Activity-normalized survey-meter assessment around patients undergoing ⁹⁹ᵐTc-pertechnetate thyroid scintigraphy: Implications for radiation protection
July 2026
Patients undergoing diagnostic nuclear medicine procedures temporarily become sources of external radiation, potentially contributing to exposure of staff, accompanying persons, and other patients....
Association of mean cardiac dose with model-predicted risk of radiation-induced pericarditis in breast cancer patients
January 2026
This study aimed to investigate the association between mean cardiac dose (MCD) and the model-predicted risk of radiation-induced pericarditis in breast cancer patients undergoing radiotherapy....
Radiation dosimetry of [124I]-metaiodobenzylguanidine (mIBG) dynamic PET/CT in pediatric neuroblastoma through animal-to-human extrapolation with MCNPX code and OLINDA/EXM software
January 2026
Iodine-124 metaiodobenzylguanidine (mIBG) positron emission tomography (PET)/computed tomography (CT) is well-established for imaging and pre-therapeutic dosimetry in pediatric neuroblastoma. However,...
Research on image segmentation of lightweight thyroid nodules
May 2026
This study aims to address the challenges inherent in thyroid nodule ultrasound image segmentation, such as excessive computational complexity, limited data availability, and the suboptimal segmentation...