Progress and challenges in infectious disease surveillance and early warning
March 2025
The increasing incidence of emerging infectious diseases emphasizes the urgent need for timely and accurate global surveillance and early warning systems. In recent years, infectious disease surveillance...
Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies
March 2025
Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors. Several international authoritative societies have developed a number of guidelines to standardize...
Cardiovascular health benefits of physical activity: aerobic, muscle-strengthening, and combined exercise modalities
June 2026
Regular physical activity (PA) has been demonstrated as one of the simplest ways to reduce the risk of incident cardiovascular disease (CVD). The specific impacts of different types of PA on cardiovascular...
The evolving landscape of mRNA-LNP medicine: advances, challenges, and future perspectives
September 2026
Messenger RNA lipid nanoparticle (mRNA-LNP) technology has developed from a successful pandemic vaccine platform into a versatile therapeutic approach applicable to infectious diseases, oncology, autoimmune...
Transforming the landscape of cancer treatment with seven promising novel therapies: evolution and future perspectives
June 2025
The landscape of cancer treatment is rapidly evolving with the emergence of promising novel therapies, offering new hope for patients with challenging malignancies. This review explores key advancements,...
The brain-bone axis: investigating the interaction between the central nervous system and skeletal homeostasis
December 2025
The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body. The skeletal system serves...
Deep brain stimulation: from mechanism to application
September 2026
Deep brain stimulation (DBS) has emerged as a transformative neuromodulation therapy for a variety of neurological and psychiatric disorders, including Parkinson’s disease, epilepsy, and obsessive-compulsive...
Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
Advancement of disease-modifying therapy of Alzheimer’s disease: from the perspective of new revised criteria for diagnosis and staging of Alzheimer’s disease
December 2025
Alzheimer’s disease (AD) imposes a substantial clinical and societal burden, yet currently approved symptomatic therapies do not modify the underlying disease biology. Recently, three anti-amyloid monoclonal...
From pathogenesis to management: therapy-related myeloid neoplasms in survivors of female-specific cancers
March 2026
As advances in diagnosis and therapy have improved survival for breast cancer and gynecologic cancer, therapy-related myeloid neoplasms (t-MN) have become one of the worst long-term consequences of...
Nitrate and body homeostasis
March 2024
Homeostasis is essential for the maintenance of health, and how it is maintained is the focus of attention in homeostatic medicine. As a natural dietary nutrient, nitrate is critical in regulating homeostasis....
Global patterns of cervical cancer incidence and mortality: updated statistics and an overview of temporal trends from 2003 to 2017
June 2025
Global disparities exist in the burden of cervical cancer. This study aims to describe and analyze the global epidemiological landscape of cervical cancer in 2022, including recent trends in incide...
The nexus of mechanical stress, integrin signaling, and endocytosis in osteoarthritis
March 2026
Osteoarthritis (OA) is a degenerative disease characterized by cartilage degeneration and joint structural damage, with its pathogenesis closely associated with abnormal mechanical stress, cellular...
Circadian rhythms in cardiovascular disease: a new perspective on inter-organ crosstalk
June 2026
Cardiovascular diseases (CVDs) constitute a global health crisis, responsible for approximately 31% of all-cause mortality, and increasingly manifest as multisystem disorders involving cardio-cerebral,...
Electroactive materials for bioelectronics and regenerative medicine: mechanisms, interfaces, and applications
June 2026
Electroactive materials, capable of generating, transmitting, and modulating electrical signals in physiological environments, have emerged as a cornerstone for bioelectronic devices and regenerative...
Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant
June 2024
With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked...
Global mortality and DALY burden across major disease categories, 1990–2021: trends, SDI-related distribution, and drivers of DALY changes
September 2026
Global disease burden is being reshaped by epidemiological and demographic transitions. We assessed global trends, the sociodemographic index (SDI)-related distribution of mortality and disability-adjusted...
Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases
December 2024
Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and other tauopathies. Intracellular...
The diagnostic accuracy of physical signs: practice experience compared with research evidence
September 2025
Physical diagnosis is the first course of clinical medicine and the first contact with patients during clinical practice. Evidence-based physical diagnosis is a helpful tool in both education and practice....
The prevalence of comorbidities and the metabolic control status in patients with diabetes mellitus in Guangdong Province of China: a cross‐sectional study
June 2026
Diabetes mellitus (DM) is a highly prevalent chronic disease worldwide and is frequently accompanied by comorbidities such as hypertension and dyslipidemia, which substantially impair patients’ quality...
Engineered microbe-based micro/nanorobots for interventional therapy of luminal cancers
September 2026
Luminal cancers, including gastrointestinal, genitourinary, and peritoneal cavity-associated malignancies, are, in principle, amenable to local intervention, yet durable therapeutic control remains...