Mechanistic study of cortex mori radices on alleviating inflammatory response in fibroblasts and enhancing lung function in COPD
Available online 22 September 2026
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition defined by persistent airway inflammation. While traditional Chinese medicine offers distinct advantages in its management,...
An eight-gene riskscore model and computational evaluation of the PDGFRB-imatinib interaction in HBV-positive hepatocellular carcinoma
Available online 22 September 2026
Chronic hepatitis B virus (HBV) infection causes persistent liver injury, fibrosis, cirrhosis, and hepatocarcinogenesis. Because hepatocellular carcinomas (HCCs) of different etiologies have distinct...
Integrated In-Silico Investigation of Pyrazolo[1,5-a]pyrimidine Scaffolds as Novel PIM-1 Kinase Inhibitor
Available online 22 September 2026
To identify the key structural and pharmacophoric features required for PIM-1 kinase inhibition with discovery of new PIM-1 kinase inhibitors based on pyrazolo[1,5-a]pyrimidine scaffolds by a combined...
Computational assessment of a predicted linarin-TNF interaction relevant to inflammation-associated oxidative stress: Network pharmacology, molecular docking, and molecular dynamics simulations
Available online 21 September 2026
Oxidative stress contributes to the progression of many chronic disorders, yet the direct molecular targets of natural antioxidants remain insufficiently defined....
Mechanism of cinobufagin in regulating pain-associated mediators in hepatocellular carcinoma based on network pharmacology and machine learning
Available online 18 September 2026
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and advanced patients often suffer from cancer pain associated with inflammatory and nociceptive factors. Cinobufagin, a steroid...
Meta-analysis of tripterygium glycosides combined with immunosuppressants or glucocorticoids in the treatment of various types of connective tissue disease-interstitial lung disease
August 2026
To systematically evaluate the efficacy of tripterygium glycosides combined with immunosuppressants or glucocorticoids in the treatment of various types of connective tissue disease-interstitial lung...
Integrated network pharmacology and single-cell analysis identify CDK4 and LGALS1 as potential targets for a modified Chaihu Shugan San formula in hepatocellular carcinoma
August 2026
This study aims to systematically elucidate the specific targets and molecular mechanisms by which modified Chaihu Shugan San (mCSS) inhibits hepatocellular carcinoma (HCC) progression to link potential...
Potential bioactive components of traditional Chinese medicine for diabetic nephropathy: Pathophysiological mechanisms and translational potential
August 2026
This review aims to systematically summarize the mechanistic insights of major traditional Chinese medicine (TCM)-derived bioactive compounds in diabetic nephropathy (DN), critically evaluate their...
Baicalin combined with docetaxel activates PANoptosis-related signaling in MCF-7 cells through the ZBP1-MLKL pathway
August 2026
Overcoming docetaxel resistance in breast cancer requires innovative combination strategies. This study reveals that baicalin synergizes with docetaxel to activate PANoptosis-related multimodal cell...
Exploration of the protective mechanism of peony decoction on DSS-induced NCM460 cell injury based on network pharmacology and in vitro validation
August 2026
Ulcerative colitis (UC) is a chronic, relapsing intestinal inflammatory disease. Although traditional Chinese medicine effectively treats UC, the systematic pharmacological mechanisms and core target...
Evolutionary shifts in representation learning for DTI prediction from sequences to structures
August 2026
Drug-target interaction prediction is an important task in computer-aided drug discovery. It supports virtual screening, drug repurposing, and lead optimization. Recent advances in deep learning have...
Chinese library classification: R733.7 document identification code: A meta-analysis of blinatumomab in the treatment of children with acute lymphoblastic leukemia
August 2026
To integrate the evidence on the effectiveness and safety of blinatumomab in the treatment of children with acute lymphoblastic leukemia (ALL) Through meta-analysis so as to provide evidence-based support...
Integrated network pharmacology, transcriptomic analysis, and preliminary cellular validation of Shenqi Dihuang decoction in clear cell renal cell carcinoma
August 2026
Shenqi Dihuang Decoction (SQD), a classical multi-component formula, may exert systems-level antitumor effects; however, its mechanisms in clear cell renal cell carcinoma (ccRCC) remain unclear....
Computational and experimental investigation of propofol- and remifentanil-associated immunometabolic modulation through amino acid transporters and AMPK–mTOR signaling in macrophages
August 2026
Propofol and remifentanil, commonly used intravenous anesthetics, exert immunomodulatory effects that may influence perioperative immune responses. Macrophage immunometabolism, governed by amino acid...
Exploring the mechanism of curcumin in the treatment of thyroid cancer based on network pharmacology and molecular docking
August 2026
Curcumin, a polyphenolic compound from Curcuma longa L., exhibits anticancer effects in various tumors. However, a systematic understanding of its multi-target molecular mechanisms in thyroid cancer...
Taurine-induced ischemic neuroprotection by modulating anti-inflammatory miRNA (miR-146a-5p and miR-125b-5p) in cerebral ischemia/reperfusion injury in rats
August 2026
Inflammatory responses significantly contribute to cerebral ischemia/reperfusion injury (CIRI). Anti-inflammatory microRNAs are recognized as endogenous regulators of neuroinflammation. Although taurine...
Centella asiatica seed extracts induce apoptosis in A549 cancer cells via the generation of ROS and suppression of IL-33 expression
August 2026
The current study aimed to investigate the anti-lung-cancer activity of various extracts of Centella asiatica (CA) seeds in the A549 cancer cell line. CA has shown anticancer properties through the...
Salidroside suppresses keloid fibroblast activation via SPHK1 as a downstream effector: Bioinformatics and in vitro experimental evidence
August 2026
Keloid disease is a fibroproliferative disorder with limited effective treatments. Salidroside has garnered significant attention for its diverse pharmacological properties....
Protective effects of Psidium guajava leaves against waterborne diisononyl phthalate toxicity and on growth of Labeo rohita
August 2026
The impact of environmental pollutants on aquatic life is a growing concern that has received considerable attention in recent years. Among these pollutants, phthalates such as Diisononyl Phthalate...
Xieyu Jiedu Granules attenuate sepsis-associated acute kidney injury through ESR1: An integrative study combining transcriptomics, network pharmacology, machine learning, and molecular docking
August 2026
Sepsis-associated acute kidney injury (SA-AKI) is a devastating disease. Xieyu Jiedu Granules (XYJDGs) are a Traditional Chinese medicine (TCM) formulation, and their constituents possess anti-inflammatory,...
Ephedrine ameliorates systemic sclerosis-associated vascular injury by facilitating macrophage efferocytosis through MerTK-ERK1/2
August 2026
Systemic sclerosis (SSc) is characterized by persistent inflammatory disorders, impaired cellular function, and vascular damage. The aim of this study is to elucidate whether ephedrine activates the...
Inhibitory effects of traditional Chinese herbal medicine Bushen decoction on osteoclast differentiation and ovariectomy-induced bone loss
August 2026
Osteoporosis (OP) is a prevalent metabolic bone disease characterized by reduced bone mineral density and compromised skeletal integrity, leading to increased fracture risk in the elderly. Current treatments...
Mechanistic insights into Xuebijing’s therapeutic effects on sepsis-induced cardiomyopathy: Transcriptomics-based approach combining WGCNA, machine learning, network pharmacology, and experimental validation
August 2026
sepsis-induced cardiomyopathy (SIC) is a critical complication of sepsis, contributing significantly to high mortality rates. The underlying molecular mechanisms remain poorly understood, and effective...
Role of health check-ups combined with pharmacological intervention in primary prevention of chronic diseases: A review based on stratified management of blood pressure and blood lipids
August 2026
Chronic diseases, particularly cardiovascular diseases (CVDs), represent the leading cause of mortality worldwide. This burden is disproportionately borne by low- and middle-income countries (LMICs),...
The combination gene therapy of HSV-TK/IL-12 inhibits non-small cell lung cancer through the bystander effect associated with Cx43 up-regulation and immune activation
August 2026
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) representing a major subtype characterized by high incidence and mortality. Despite...